%0 Journal Article
%T A prime-boost vaccination strategy using a Semliki Forest virus replicon vectored DNA vaccine followed by a recombinant adenovirus protects pigs from classical swine fever<br>猪瘟甲病毒复制子载体DNA疫苗与重组腺病毒活载体疫苗联合免疫效果评价
%A Yuan Sun
%A Dafei Liu
%A Yufei Wang
%A Na Li
%A Hongyu Li
%A Bingbing Liang
%A Huaji Qiu
%A <br>孙元
%A 刘大飞
%A 王宇飞
%A 李娜
%A 李宏宇
%A 梁冰冰
%A 仇华吉
%J 生物工程学报
%D 2009
%I 
%X We have previously evaluated a Semliki Forest virus(SFV) replicon vectored DNA vaccine(pSFV1CS2-E2) and a recombinant adenovirus(rAdV-E2) expressing the E2 glycoprotein of classical swine fever virus(CSFV) in pigs.The results showed that the immunized pigs were protected from virulent challenge, but few pigs showed short-term fever and occasional pathological changes following virulent challenge.To enhance the immunogenecity of the vaccines, we tried a prime-boost vaccination strategy using a combination of...
%K classical swine fever virus
%K alphavirus replicon vector
%K DNA vaccine
%K recombinant adenovirus
%K prime-boost<br>猪瘟
%K 甲病毒复制子载体
%K DNA疫苗
%K 重组腺病毒
%K 联合免疫
%U http://www.alljournals.cn/get_abstract_url.aspx?pcid=90BA3D13E7F3BC869AC96FB3DA594E3FE34FBF7B8BC0E591&jid=A66E90C274451689E69F6F0291467824&aid=0B1F3E6AADD61DF27EF1EFB42E8D47F8&yid=DE12191FBD62783C&vid=C5154311167311FE&iid=94C357A881DFC066&sid=DC06EBDBAF4E06D3&eid=AF14A8B15FB15A64&journal_id=1000-3061&journal_name=生物工程学报&referenced_num=3&reference_num=17