%0 Journal Article
%T Progress in new vaccine strategies against influenza: a review<br>流感疫苗研制的新策略
%A Zhihui Liu
%A Tao Jiang
%A Ede Qin
%A Duoliang Ran
%A Chengfeng Qin
%A <br>刘志辉
%A 姜涛
%A 秦鄂德
%A 冉多良
%A 秦成峰
%J 生物工程学报
%D 2012
%I 
%X Influenza, caused by influenza virus, is a serious respiratory illness which poses a global public health threat. Vaccination is the primary strategy for the prevention and control of influenza. Although both inactivated vaccines and the live attenuated vaccines are effective in preventing influenza, the current vaccines have poor efficacy in the elderly and fail to provide protection against heterosubtype viruses. Development of a safer and more effective influenza vaccine that provides broad cross protection, overcoming the intrinsic limitation of the current vaccines, has been a scientific challenge. During the past decades, structural biology, reverse genetic and other virological technologies developed quickly and sped the progress of influenza vaccinology. Some new strategies for developing influenza vaccine have been generated, produced encouraging results, which showed great prospect as next-generation of influenza vaccines.
%K influenza virus
%K vaccine
%K new technologies
%K elastase
%K virus-like particle<br>流感病毒，疫苗，新技术，弹性蛋白酶，病毒样颗粒
%U http://www.alljournals.cn/get_abstract_url.aspx?pcid=90BA3D13E7F3BC869AC96FB3DA594E3FE34FBF7B8BC0E591&jid=A66E90C274451689E69F6F0291467824&aid=13A5D5D02B8AA8701C3B616FB5B52755&yid=99E9153A83D4CB11&vid=D3E34374A0D77D7F&iid=94C357A881DFC066&sid=64808317C39DF331&eid=CF0706A3E35031F6&journal_id=1000-3061&journal_name=生物工程学报&referenced_num=0&reference_num=0