%0 Journal Article
%T Progress in genome-scale metabolic network: a review<br>基因组尺度代谢网络研究进展
%A Hui Wang
%A Hongwu Ma
%A Xueming Zhao
%A <br>王晖
%A 马红武
%A 赵学明
%J 生物工程学报
%D 2010
%I 
%X Dozens of genome-scale metabolic networks have been reconstructed by integrating information from various databases on genes, proteins, metabolites and validated by experiment data from the literature. The reconstructed networks can be used to quantitatively investigate the interactions between components of a biological system at a system level. Such theoretical study could help us understand the organization principle of the large scale network and thus provide guidance to strain optimization through metabolic engineering technology. In this review, we evaluate the methods for the reconstruction, analysis and application of genome-scale metabolic networks. The difficulties and perspectives on this emerging research field are also discussed.
%K genome-scale
%K metabolic network
%K systems biology
%K metabolic engineering<br>基因组尺度，代谢网络，系统生物学，代谢工程
%U http://www.alljournals.cn/get_abstract_url.aspx?pcid=90BA3D13E7F3BC869AC96FB3DA594E3FE34FBF7B8BC0E591&jid=A66E90C274451689E69F6F0291467824&aid=2F48237A49F9ED334205E9739D74813A&yid=140ECF96957D60B2&vid=96C778EE049EE47D&iid=F3090AE9B60B7ED1&sid=CEEFA682892739FB&eid=A9974A3EA5885863&journal_id=1000-3061&journal_name=生物工程学报&referenced_num=0&reference_num=0