%0 Journal Article
%T Recent Advances in the Production of Heterologous Proteins in Filamentous Fungi<br>丝状真菌高效表达异源蛋白研究进展
%A Yaohua Zhong
%A Xiaoli Wang
%A Tianhong Wang
%A <br>钟耀华
%A 王晓利
%A 汪天虹
%J 生物工程学报
%D 2008
%I 
%X Filamentous fungi can secrete large amounts of proteins, glycosylate proteins and grow faster than plant, insect or mammalian cells. With the advances in fungal molecular genetics, strain improvement, and especially fungal genomics, filamentous fungi are developed as microbial cell factories for the production of heterologous proteins. This review focuses on recent developments of filamentous fungi as production hosts, such as protein quality control mechanisms, the secretion pathways, protein modification, strain stability, and most importantly the application of functional genomics in protein expression. At the same time, the strategies for improving heterologous protein production were also discussed in details.
%K filamentous fungi
%K heterologous protein expression
%K protein secretion
%K protein glycosylation
%K fungal genomics<br>丝状真菌
%K 异源蛋白表达
%K 蛋白质分泌
%K 蛋白质糖基化
%K 功能基因组学
%U http://www.alljournals.cn/get_abstract_url.aspx?pcid=90BA3D13E7F3BC869AC96FB3DA594E3FE34FBF7B8BC0E591&jid=A66E90C274451689E69F6F0291467824&aid=1F94A3E5CAB8D652A4F03FF54455E1A0&yid=67289AFF6305E306&vid=B91E8C6D6FE990DB&iid=E158A972A605785F&sid=20ADD38F841C6A4B&eid=DFBC046213B3DD86&journal_id=1000-3061&journal_name=生物工程学报&referenced_num=0&reference_num=78