%0 Journal Article
%T Plant-specific type III polyketide synthases superfamily: crystal structures and functions<br>植物类型III聚酮合酶超家族晶体结构与功能
%A Lü Heshu
%A Liu Chunmei
%A Lu Ping
%A Shi Guanglu
%A Ma Lanqing
%A Wang Younian
%A <br>吕鹤书
%A 柳春梅
%A 路平
%A 师光禄
%A 马兰青
%A 王有年
%J 生物工程学报
%D 2012
%I 
%X Plant type III polyketide synthase (PKS) generates backbones of a variety of plant secondary metabolites with diverse functions, and has long been models to elucidate the relationship between the three-dimensional structure and function. More than 80 type III PKS crystal structures with different functions have been reported in Protein Data Bank, including the crystal structures of the well-studied Chalcone Synthase of plant type III PKS, as well as the 6 other kinds of PKSs in the family, which are critical for understanding the structural basis for diverse starter molecule selectivity, polyketide chain length and the cyclization reaction. Structure-based analysis and site-directed mutagenesis are foundation for the investigation of enzyme engineering, genetic and metabolic engineering. This review summarized 7 plant-specific type III PKS in the aspects of their crystal structures and functions.
%K polyketide synthase
%K chalcone synthase
%K crystal structure<br>聚酮合酶，查尔酮合酶，晶体结构
%U http://www.alljournals.cn/get_abstract_url.aspx?pcid=90BA3D13E7F3BC869AC96FB3DA594E3FE34FBF7B8BC0E591&jid=A66E90C274451689E69F6F0291467824&aid=8207906E12F691D6F5EF3052E7FE2FAA&yid=99E9153A83D4CB11&vid=D3E34374A0D77D7F&iid=CA4FD0336C81A37A&sid=CA4FD0336C81A37A&eid=F3583C8E78166B9E&journal_id=1000-3061&journal_name=生物工程学报&referenced_num=0&reference_num=0