%0 Journal Article
%T COMPUTATIONAL SYSTEMS BIOLOGICAL RESEARCH ON IDENTIFYING TARGET GENES AND CONSTRUCTING NETWORKS FOR COMPLEX DISEASES<br>复杂疾病靶基因识别与网络重建的计算系统生物研究
%A Li Xia
%A Jiang Wei
%A Zhang Fan
%A <br>李霞
%A 姜伟
%A 张帆
%J 生物物理学报
%D 2007
%I 
%X Identifying target genes, constructing disease-driven gene networks for complex diseases and further research on pathogenesis are the key fields in the function genomics study. From computa-tional systems biological and three dimensional viewpoints, the authors carefully review on identifying tar-get genes based on biological profiles (SNP genetic profiles, gene expression profiles, 2D-PAGE protein profiles and so on) for complex diseases, reverse engineering genetic networks from multi-levels (SNPs dummy networks, gene regulatory networks, protein-protein interaction networks and so on) and portrait matching these heterogeneous networks from biology and topology. Furthermore, the authors also prospect the computational systems biological research on identification of target genes and construction of genetic networks for complex diseases.
%K Biological profiles
%K Gene mining
%K Gene network reconstruction
%K Portrait matching
%K Com-putational systems biology<br>生物谱
%K 基因识别
%K 网络重建
%K 纵向映射
%K 计算系统生物
%U http://www.alljournals.cn/get_abstract_url.aspx?pcid=90BA3D13E7F3BC869AC96FB3DA594E3FE34FBF7B8BC0E591&jid=E0C9D9BBED813D6674AC13E942EAC86D&aid=B529B1FF923ECE77&yid=A732AF04DDA03BB3&vid=EA389574707BDED3&iid=E158A972A605785F&sid=D0182A31A5EB14BA&eid=31BCE06A2FD82A16&journal_id=1000-6737&journal_name=生物物理学报&referenced_num=0&reference_num=81