%0 Journal Article
%T Optimized Pyruvate Production Through Enhancing Torulopsis glabrata Process Performance<br>丙酮酸发酵过程中光滑球拟酵母过程功能的强化
%A Qinglong Xu
%A Liming Liu
%A Guocheng Du
%A Jian Chen
%A <br>许庆龙
%A 刘立明
%A 堵国成
%A 陈 坚
%J 生物工程学报
%D 2008
%I 
%X Based on kinetic parameters analysis, a 4-stage glucose-control strategy was used to optimize pyruvate production by Torulopsis glabrata. At 0~18 h, 40 g/L glucose was fed to get a higher specific growth rate, and then glucose was quickly fed to the fermentation broth at 19~25 h to achieve the maximum dry cell concentration and to redirect the carbon flux from cell growth to pyruvate formation. At 26~63 h, a highest pyruvate yield (0.71 g/g) was achieved through maintaining glucose at 33.4 g/L by a singular control strategy. After 64 h, pyruvate fermentation was continued as batch process. A high concentration (83.1 g/L), yield (0.621 g/g) and productivity (1.00 g/(L·h)) of pyruvate were achieved by applying this strategy, which were 21.3%, 21.6% and 29.9% higher than that of the batch process.
%K Torulopsis glabrata
%K glucose concentration shifting strategy
%K pyruvate production<br>光滑球拟酵母
%K 过程功能
%K 强化策略
%U http://www.alljournals.cn/get_abstract_url.aspx?pcid=90BA3D13E7F3BC869AC96FB3DA594E3FE34FBF7B8BC0E591&jid=A66E90C274451689E69F6F0291467824&aid=11E8CDEA36FD9A10FAD9D9B40DC5FB92&yid=67289AFF6305E306&vid=B91E8C6D6FE990DB&iid=CA4FD0336C81A37A&sid=C36EC077A8A90308&eid=8C83C265AD318E34&journal_id=1000-3061&journal_name=生物工程学报&referenced_num=0&reference_num=20