%0 Journal Article
%T THE EFFECT OF SOLUBLE AND FIBRILAR Aβ1-40 ON MEMBRANE PERMEABILITY<br>可溶的和纤维化的Aβ1-40对膜脂的通透性的影响
%A MA Xiao-cui
%A SHA Yin-lin
%A LIN Ke-chun
%A NIE Song-qing
%A <br>马晓翠
%A 沙印林
%A 林克椿
%A 聂松青
%J 生物物理学报
%D 2002
%I 
%X The time course of Aa 1-40 fibril formation was characterized using a variety of assays. The effect of soluble and fibrillar Aa 1-40 on the membrane permeability was assessed by measuring the re-l ease of vesicle-entrapped with three different molecular weight fluoresc ence probes (ANTS/DPX, Calcein, FD-4). The results showed that fibrils had formed after 4 days. Aggregated Aa 1-40 may induce the leakage of ANTS and Calcein in a dose-dependent manner, but soluble Aa 1-40 had no such effect. It suggests that the change of physico-chemi cal properties of membrane constituents may have some relation to Aa neuro-toxicity.
%K Soluble Aa 1-40
%K Fibrilar Aa 1-40
%K Membrane
%K Leakage<br>膜脂
%K 通透性
%K AD
%K 漏出
%K 可溶性Aβ1－40
%K 纤维化Aβ1－40
%K 早老性痴呆
%U http://www.alljournals.cn/get_abstract_url.aspx?pcid=90BA3D13E7F3BC869AC96FB3DA594E3FE34FBF7B8BC0E591&jid=E0C9D9BBED813D6674AC13E942EAC86D&aid=720036CD5E56FED0&yid=C3ACC247184A22C1&vid=13553B2D12F347E8&iid=38B194292C032A66&sid=4133DDB79B497495&eid=11CEECA6DA9E4AC5&journal_id=1000-6737&journal_name=生物物理学报&referenced_num=3&reference_num=11