%0 Journal Article
%T THE EFFECT OF THE ANTIC ANCER DRUG CIS-DDP ON THE DENATURATION OF DNA<br>抗癌药物顺铂对DNA结构的影响
%A 沈子威
%A 王昶
%A 沈淑敏
%J 生物物理学报
%D 1990
%I 
%X Cis-diamminedchloroplatinum( II ) (cis-DDP) is a kind of antitumous medicine. It bonds to the N-7 of the guanine of DNA and causes intrastrand or intrastrand cross - linking. Our experiments induce fluorecence techniques to analyze the influence of cis-DDP on DNA denaturation so as to give some information on the interaction between cis-DDP and DNA. The results are as fellows:(1) proved that as - DDP made hydrogen bond of G - C easy to be damaged in vitro.(2) Got the percent of damaged hydrogen bonding in DNA at different temperature befor and after cis-DDP was added(3) the influence of the percent of G-C base in DNA.(4) the influence of the concentration of cis-DDP(5) the brief discussion of the mechanism of antitumor
%K 抗癌药物
%K 顺铂
%K DNA结构
%U http://www.alljournals.cn/get_abstract_url.aspx?pcid=90BA3D13E7F3BC869AC96FB3DA594E3FE34FBF7B8BC0E591&jid=E0C9D9BBED813D6674AC13E942EAC86D&aid=75B996B9389E4AD40BBA887F03C9EF21&yid=8D39DA2CB9F38FD0&vid=B31275AF3241DB2D&iid=0B39A22176CE99FB&sid=7979125BBE749348&eid=5D8C08279A19B0D4&journal_id=1000-6737&journal_name=生物物理学报&referenced_num=0&reference_num=1