%0 Journal Article
%T Transgenic Animals Bioreactors<br>动物乳腺生物反应器的现状和趋势
%A Ke-Mian Gou
%A Xiao-Rong An
%A Jian-Hui Tian
%A Yong-Fu Chen
%A <br>苟克勉
%A 安晓荣
%A 田见晖
%A 陈永福
%J 生物工程学报
%D 2002
%I 
%X The production of human recombinant proteins in milk of transgenic farm animals offers a safe, very cost effective source of commercially important proteins that cannot be produced as efficiently in adequate quantities by other methods. This review has summarized the current status of gene selection, vector construct, transgenic methods, economics, and obvious potential in transgenic animals bioreactors. Recently, a more powerful approach was adopted in the transgenic animals founded on the application of nuclear transfer. As we will illustrate, this strategy presents a breakthrough in the overall efficiency of generating transgenic farm animals, product consistency, and time of product development. The successful adaptation of Cre / lox P mediated site specific DNA recombination systems in farm animals will offer unprecedented possibilities for generating transgenic animals.
%K transgenic animals
%K mammary gland
%K bioreactors
%K nuclear transfer<br>转基因动物，
%K 乳腺，生物反应器，
%K 核移植
%U http://www.alljournals.cn/get_abstract_url.aspx?pcid=90BA3D13E7F3BC869AC96FB3DA594E3FE34FBF7B8BC0E591&jid=A66E90C274451689E69F6F0291467824&aid=5C15313196D10898&yid=C3ACC247184A22C1&vid=13553B2D12F347E8&iid=0B39A22176CE99FB&sid=3986B25773CB6C30&eid=856C2E13D1000DB7&journal_id=1000-3061&journal_name=生物工程学报&referenced_num=20&reference_num=42