%0 Journal Article
%T STUDY ON THE HEMORHEOLOGY OF 615-STRAIN MICE AFTER TRANSPLANTATION OF METASTATIC AND NON-METASTATIC TUMORS<br>转移及非转移肿瘤移植后615小鼠血液流变学变化的研究
%A 于小波
%A 高进
%A 薛克勋
%A 赵雪梅
%A 周梦龄
%J 生物物理学报
%D 1991
%I 
%X Tumor cells FC (haematogenous metastasis) , U14 (lymphatic and haematoge-neous metastasis) , H22 (lymphatic metastasis) and P615 (non-metastasis) were respectively transplanted into inbred 615-strain mice. These mice were killed on different days after the transplantation of the tumor cells for histological and he-morheological examinations. Based on the histological findings the development of the metastatic tumors were divided into 5 stages, namely latent stage, invasive stage, early metastatic stage, middle metastatic stage and late metastatic stage and the development of the non-metastatic tumor was divided into 4 stages, namely latent stge,proliferative stage,stage of cyst-formation and stage of central necrosis. The results of the experiment indicated that the plasma and blood viscosity both elevated in early periods of metastatic tumor development and decreased in late periods of above processes, the aggregation and haematocrit of red blood cells also dropped but thier rigidity increased in late periods of metastatic tumor development. Above hemorheological changes were started at latent stage (earliest) for tumor FC of haematogenous metastasis, at invasive stage (later) for tumor U14 of lymphatic and haematogenous metastasis, in early metastatic stage (latest) for tumor H22 of lymphatic metastasis. The changes of the hemorheological values were larger after transplantions of both haematogenous metastatic tumor FC and lymphatic and haematogenous metastatic tumor U14. The changes of hemorheological values after transplantation of lymphatic metastatic tumor H22 were smaller than the changes of above FC and U14. Most hemorheological values were keeping in steady levels in the whole development process of non-metastasis tumor P615. The relationship between invasion and metastasis of tumor and hemorheological changes were discussed. The significances of above results for diagnosing and treating of tumor patients were analyzed.
%K tumor invasion
%K tumor metastasis
%K inbied 615-strain mice
%K hemor-heology<br>肿瘤转移
%K 血液流变学
%K 血液粘度
%U http://www.alljournals.cn/get_abstract_url.aspx?pcid=90BA3D13E7F3BC869AC96FB3DA594E3FE34FBF7B8BC0E591&jid=E0C9D9BBED813D6674AC13E942EAC86D&aid=5E86E445AE6962DC0E28BC6F6F52EA29&yid=116CB34717B0B183&vid=DF92D298D3FF1E6E&iid=E158A972A605785F&sid=4D4C81DBA842B7BD&eid=D93AD940782892D0&journal_id=1000-6737&journal_name=生物物理学报&referenced_num=0&reference_num=9