%0 Journal Article
%T STRUCTURAL BASIS OF FUNCTIONAL SPECIFICITYOF STEROID RECEPTORS<br>甾体激素受体功能特异性的结构基础
%A ZHANG Qing
%A YE Yu-zhen
%A DING Da-fu
%A <br>张磬
%A 叶玉珍
%A 丁达夫
%J 生物物理学报
%D 2001
%I 
%X The steroid receptors include the estrogen receptor, androgen receptor, progesterone receptor, glucocorticoid receptor and mineralocorticoid receptor. They are involved in almost all physiological activities, including reproduction,homeostasis,cell proliferation, differentiation and death. Elucidating the specificity of steroid receptors' subfamily will deepen understanding of their functions and has potential pharmaceutical applications. The evolutionary trace method was used to analyze structural basis of functional specificity of steroid receptors. Results indicated that steroid receptors and its endogenous ligands may experience some coevolutionary process;trace residues in ligand-binding sites display different hydrogen-bond interactions and van der Waals contacts between receptors and its ligands,which decide subfamilies' ligand binding specificity.These informations can be used to modify ligand specificity of steroid receptors and design tissue-selective ligands(e.g. selective estrogen receptor modulator).
%K Steroid receptor
%K Ligand-binding domain
%K Weighted evolutionary tracing
%K Specific residue<br>甾体激素受体
%K 配体结合域
%K 加权进化踪迹分析
%K 踪迹残基
%K 特异性
%U http://www.alljournals.cn/get_abstract_url.aspx?pcid=90BA3D13E7F3BC869AC96FB3DA594E3FE34FBF7B8BC0E591&jid=E0C9D9BBED813D6674AC13E942EAC86D&aid=D4604EE2BB1D6D35&yid=14E7EF987E4155E6&vid=BCA2697F357F2001&iid=E158A972A605785F&sid=AF14A8B15FB15A64&eid=D02611D1F8166C9A&journal_id=1000-6737&journal_name=生物物理学报&referenced_num=2&reference_num=28