%0 Journal Article
%T The New Antiendotoxin Strategies<br>抗内毒素治疗的新策略
%A WANG Dong
%A |Ning
%A ZHANG Wei
%A |Jie
%A WU Xiang
%A |Fu
%A <br>王东宁
%A 张惟杰
%A 吴祥甫
%J 生物工程学报
%D 2001
%I 
%X Lipopolysaccharide(LPS)is important in the pathogenesis of sepsis infected by gram\|negative bacteria in humans,and part or all of this pathophysiology is mediated by a complex secondary inflammatory response.Administration of purified LPS or a variety of LPS\|free recombinant mediators can reproduce much of the pathophysiology of gram\|negative sepsis.There has been an explosion of new information over the last several years regarding the interactions of LPS with proteins and cells.Blocking sepsis at the bacterial toxin level is appealing because it is upstream,so that the secondary pathologic inflammatory cascade may be limited or prevented.A variety of antiendotoxin strategies have been proposed.Therapies under investigation include agents that bind and neutralize LPS,agents or systems that enhance LPS clearance,and agents that inhibit LPS interaction with serum elements or cellular receptors.
%K G
%K -endotoxin
%K LPS\|binding proteins
%K antiendotoxin strategies<br>细菌内毒素，LPS结合蛋白，抗内毒素治疗
%U http://www.alljournals.cn/get_abstract_url.aspx?pcid=90BA3D13E7F3BC869AC96FB3DA594E3FE34FBF7B8BC0E591&jid=A66E90C274451689E69F6F0291467824&aid=9C94C099645A353C&yid=14E7EF987E4155E6&vid=BCA2697F357F2001&iid=38B194292C032A66&sid=6A73B36E85DB0CE9&eid=E2E0FBFE4D7EFB94&journal_id=1000-3061&journal_name=生物工程学报&referenced_num=11&reference_num=33