%0 Journal Article
%T Folding of Matrix Metalloproteinase-2 Prevents Endogenous Generation of MHC Class-I Restricted Epitope
%A Virginie Renaud
%A Emmanuelle Godefroy
%A Pierre Larrieu
%A Fabrice Fleury
%A Francine Jotereau
%A Yannick Guilloux
%J PLOS ONE
%D 2012
%I Public Library of Science (PLoS)
%R 10.1371/journal.pone.0011894
%X We previously demonstrated that the matrix metalloproteinase-2 (MMP-2) contained an antigenic peptide recognized by a CD8 T cell clone in the HLA-A*0201 context. The presentation of this peptide on class I molecules by human melanoma cells required a cross-presentation mechanism. Surprisingly, the classical endogenous processing pathway did not process this MMP-2 epitope.
%U http://www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0011894