%0 Journal Article
%T A COMPARATIVE STUDY OF THE ACTION OF 8-Br-cGMP AND cGMP ON THE LIGHT-SENSITIVE CHANNEL IN TOAD RODS<br>8-Br-cGMP和cGMP对蟾蜍视杆光敏感通道作用的比较研究
%A 颜坤
%A 加里.马修斯
%J 生物物理学报
%D 1991
%I 
%X Patch-clamp recordings were made from rod outer segments (ROS) of toad retina. 8-Br-cGMP opened a channel that appeared to be the same as light-sensitive channel, which was opened by cGMP from the same patch. Under the same patch membrane potential, 8-Br-cGMP also caused membrane current to increase to about the same magnitude from the same patch as did cGMP. However, the 8-Br-cGMP concentration was much lower than the cGMP concentration. Moreover, the rate which 8-Br-cGMP was hydrolyzed by phosphodiesterase is much more slowly than that cGMP did. The results suggest that 3', 5'-cyclic monophoshate of cGMP molecule plays an important role in opening the light-sensitive channel of ROS.
%K 视杆
%K 光敏感通道
%K 蟾蜍
%K cGMP
%U http://www.alljournals.cn/get_abstract_url.aspx?pcid=90BA3D13E7F3BC869AC96FB3DA594E3FE34FBF7B8BC0E591&jid=E0C9D9BBED813D6674AC13E942EAC86D&aid=5E86E445AE6962DCC29416EA8A072E5F&yid=116CB34717B0B183&vid=DF92D298D3FF1E6E&iid=CA4FD0336C81A37A&sid=67969BA850333433&eid=46CB27789995047D&journal_id=1000-6737&journal_name=生物物理学报&referenced_num=0&reference_num=0