%0 Journal Article
%T Evidence for Sub-Haplogroup H5 of Mitochondrial DNA as a Risk Factor for Late Onset Alzheimer's Disease
%A Aurelia Santoro
%A Valentina Balbi
%A Elisa Balducci
%A Chiara Pirazzini
%A Francesca Rosini
%A Francesca Tavano
%A Alessandro Achilli
%A Paola Siviero
%A Nadia Minicuci
%A Elena Bellavista
%A Michele Mishto
%A Stefano Salvioli
%A Francesca Marchegiani
%A Maurizio Cardelli
%A Fabiola Olivieri
%A Benedetta Nacmias
%A Andrea Maria Chiamenti
%A Luisa Benussi
%A Roberta Ghidoni
%A Giuseppina Rose
%A Carlo Gabelli
%A Giuliano Binetti
%A Sandro Sorbi
%A Gaetano Crepaldi
%A Giuseppe Passarino
%A Antonio Torroni
%A Claudio Franceschi
%J PLOS ONE
%D 2012
%I Public Library of Science (PLoS)
%R 10.1371/journal.pone.0012037
%X Alzheimer's Disease (AD) is the most common neurodegenerative disease and the leading cause of dementia among senile subjects. It has been proposed that AD can be caused by defects in mitochondrial oxidative phosphorylation. Given the fundamental contribution of the mitochondrial genome (mtDNA) for the respiratory chain, there have been a number of studies investigating the association between mtDNA inherited variants and multifactorial diseases, however no general consensus has been reached yet on the correlation between mtDNA haplogroups and AD.
%U http://www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0012037