%0 Journal Article
%T Thymic Alterations in GM2 Gangliosidoses Model Mice
%A Seiichi Kanzaki
%A Akira Yamaguchi
%A Kayoko Yamaguchi
%A Yoshitsugu Kojima
%A Kyoko Suzuki
%A Noriko Koumitsu
%A Yoji Nagashima
%A Kiyotaka Nagahama
%A Michiko Ehara
%A Yoshio Hirayasu
%A Akihide Ryo
%A Ichiro Aoki
%A Shoji Yamanaka
%J PLOS ONE
%D 2012
%I Public Library of Science (PLoS)
%R 10.1371/journal.pone.0012105
%X Sandhoff disease is a lysosomal storage disorder characterized by the absence of ¦Â-hexosaminidase and storage of GM2 ganglioside and related glycolipids. We have previously found that the progressive neurologic disease induced in Hexb£¿/£¿ mice, an animal model for Sandhoff disease, is associated with the production of pathogenic anti-glycolipid autoantibodies.
%U http://www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0012105