%0 Journal Article
%T Calcineurin Interacts with PERK and Dephosphorylates Calnexin to Relieve ER Stress in Mammals and Frogs
%A Mariana Bollo
%A R. Madelaine Paredes
%A Deborah Holstein
%A Nadezhda Zheleznova
%A Patricia Camacho
%A James D. Lechleiter
%J PLOS ONE
%D 2012
%I Public Library of Science (PLoS)
%R 10.1371/journal.pone.0011925
%X The accumulation of misfolded proteins within the endoplasmic reticulum (ER) triggers a cellular process known as the Unfolded Protein Response (UPR). One of the earliest responses is the attenuation of protein translation. Little is known about the role that Ca2+ mobilization plays in the early UPR. Work from our group has shown that cytosolic phosphorylation of calnexin (CLNX) controls Ca2+ uptake into the ER via the sarco-endoplasmic reticulum Ca2+-ATPase (SERCA) 2b.
%U http://www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0011925