%0 Journal Article
%T Progress in Telomerase and the Inhibitors<br>端粒酶及其抑制剂的研究进展
%A ZHOU Yuan
%A GONG Xing
%A |Guo
%A <br>周远
%A 龚兴国
%J 生物工程学报
%D 2001
%I 
%X In cells division chromosome length is shorten for the ending DNA couldn't be replicated completely, and the loss of telomere DNA will lead to senescence and death. Activation of telomerase can elongate telomere length and maintain gene stability. Up-regulation of telomerase is considered to be responsible for immortalization and carcinogenesis. It plays an important role in cell-span and cell division. The telomerase inhibitors will become efficient drugs in tumor therapy.
%K telomerase
%K detecting
%K cancer
%K telomerase inhibitors<br>端粒酶
%K 活性测定
%K 肿瘤治疗
%K 端粒酶抑制剂
%U http://www.alljournals.cn/get_abstract_url.aspx?pcid=90BA3D13E7F3BC869AC96FB3DA594E3FE34FBF7B8BC0E591&jid=A66E90C274451689E69F6F0291467824&aid=D93D6A1162CF544F&yid=14E7EF987E4155E6&vid=BCA2697F357F2001&iid=B31275AF3241DB2D&sid=1A0C7C60D40EFD74&eid=D647AF4730396036&journal_id=1000-3061&journal_name=生物工程学报&referenced_num=3&reference_num=21