%0 Journal Article
%T Rational Selection of Spiramycin-producing Strain<br>螺旋霉素产生菌的推理选育
%A Jin Zhihua
%A <br>金志华
%J 生物工程学报
%D 1995
%I 
%X The biosynthetic pathway of spiramycin were used for rational selection of spiramycin-producing strain. First, the L-valine-resistant mutant strains were selected, the productivity of the highest one of these strains increased 24%. Second the mutant strains resistant to a-aminobutyric acid were screened, the productivity of the highest one of these strains raised 26%. Finally, strain XC-533, whose genetics property of high productivity was stable, was gained by purification. The potency of the strain XC-533 had been increased 20% by production medium improvement. The fermentation of the new strain XC-533 was performed in 7m3 fermenter, and it made the potency and index of fermentation enhanced 73.19% and 32.14%, respectively.
%K Spiramycin
%K biosynthetic pathway
%K rational selection<br>螺旋霉素产生菌
%K 螺旋霉素
%K 抗菌素
%K 发酵
%K 选育
%U http://www.alljournals.cn/get_abstract_url.aspx?pcid=90BA3D13E7F3BC869AC96FB3DA594E3FE34FBF7B8BC0E591&jid=A66E90C274451689E69F6F0291467824&aid=A135961C5A1C1D16AAB83C9D58A2ED4F&yid=BBCD5003575B2B5F&vid=708DD6B15D2464E8&iid=38B194292C032A66&sid=AF507FDD66D991DA&eid=D0182A31A5EB14BA&journal_id=1000-3061&journal_name=生物工程学报&referenced_num=0&reference_num=3