%0 Journal Article
%T Myc Promoter-Binding Protein-1 (MBP-1) Is a Novel Potential Prognostic Marker in Invasive Ductal Breast Carcinoma
%A Mariavera Lo Presti
%A Arianna Ferro
%A Flavia Contino
%A Claudia Mazzarella
%A Silvia Sbacchi
%A Elena Roz
%A Carmelo Lupo
%A Giovanni Perconti
%A Agata Giallongo
%A Paola Migliorini
%A Antonio Marrazzo
%A Salvatore Feo
%J PLOS ONE
%D 2012
%I Public Library of Science (PLoS)
%R 10.1371/journal.pone.0012961
%X Alpha-enolase is a glycolytic enzyme that catalyses the formation of phosphoenolpyruvate in the cell cytoplasm. ¦Á-Enolase and the predominantly nuclear Myc promoter-binding protein-1 (MBP-1) originate from a single gene through the alternative use of translational starting sites. MBP-1 binds to the P2 c-myc promoter and competes with TATA-box binding protein (TBP) to suppress gene transcription. Although several studies have shown an antiproliferative effect of MBP-1 overexpression on several human cancer cells, to date detailed observations of ¦Á-enolase and MBP-1 relative expression in primary tumors versus normal tissues and their correlation with clinicopathological features have not been undertaken.
%U http://www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0012961