%0 Journal Article
%T Antibody Targeting of Cathepsin S Inhibits Angiogenesis and Synergistically Enhances Anti-VEGF
%A Claire Ward
%A Diana Kuehn
%A Roberta E. Burden
%A Julie A. Gormley
%A Thomas J. Jaquin
%A Mihaela Gazdoiu
%A Donna Small
%A Roy Bicknell
%A James A. Johnston
%A Christopher J. Scott
%A Shane A. Olwill
%J PLOS ONE
%D 2012
%I Public Library of Science (PLoS)
%R 10.1371/journal.pone.0012543
%X Angiogenesis is a key hallmark of tumourigenesis and its inhibition is a proven strategy for the development of novel anti-cancer therapeutics. An important aspect of early angiogenesis is the co-ordinated migration and invasion of endothelial cells through the hypoxic tumour tissue. Cathepsin S has been shown to play an important role in angiogenesis as has vascular endothelial growth factor (VEGF). We sought to assess the anti-angiogenic effect of Fsn0503, a novel cathepsin S inhibitory antibody, when combined with anti-VEGF on vascular development.
%U http://www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0012543