%0 Journal Article
%T Functional Variant in Complement C3 Gene Promoter and Genetic Susceptibility to Temporal Lobe Epilepsy and Febrile Seizures
%A Sarah Jamali
%A Annick Salzmann
%A Nader Perroud
%A Magali Ponsole-Lenfant
%A Jennifer Cillario
%A Patrice Roll
%A Nathalie Roeckel-Trevisiol
%A Ariel Crespel
%A Jorg Balzar
%A Kurt Schlachter
%A Ursula Gruber-Sedlmayr
%A Ekaterina Pataraia
%A Christoph Baumgartner
%A Alexander Zimprich
%A Fritz Zimprich
%A Alain Malafosse
%A Pierre Szepetowski
%J PLOS ONE
%D 2012
%I Public Library of Science (PLoS)
%R 10.1371/journal.pone.0012740
%X Human mesial temporal lobe epilepsies (MTLE) represent the most frequent form of partial epilepsies and are frequently preceded by febrile seizures (FS) in infancy and early childhood. Genetic associations of several complement genes including its central component C3 with disorders of the central nervous system, and the existence of C3 dysregulation in the epilepsies and in the MTLE particularly, make it the C3 gene a good candidate for human MTLE.
%U http://www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0012740