%0 Journal Article
%T Green Tea Catechin, Epigallocatechin Gallate, Suppresses Signaling by the dsRNA Innate Immune Receptor RIG-I
%A C. T. Ranjith-Kumar
%A Yvonne Lai
%A Robert T. Sarisky
%A C. Cheng Kao
%J PLOS ONE
%D 2012
%I Public Library of Science (PLoS)
%R 10.1371/journal.pone.0012878
%X The Innate immune system constitutes the first line of defense against pathogen infections. The Retinoic acid-inducible gene I (RIG-I) receptor recognizes triphosphorylated ssRNAs and dsRNA to initiate downstream signaling of interferon response. However, unregulated activity of these receptors could lead to autoimmune diseases. We seek to identify small molecules that can specifically regulate RIG-I signaling.
%U http://www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0012878