%0 Journal Article
%T Bacterial Flagellin Triggers Cardiac Innate Immune Responses and Acute Contractile Dysfunction
%A Joelle Rolli
%A Nathalie Rosenblatt-Velin
%A Jianhui Li
%A Noureddine Loukili
%A Sandra Levrand
%A Pal Pacher
%A Bernard Waeber
%A Fran£żois Feihl
%A Patrick Ruchat
%A Lucas Liaudet
%J PLOS ONE
%D 2012
%I Public Library of Science (PLoS)
%R 10.1371/journal.pone.0012687
%X Myocardial contractile failure in septic shock may develop following direct interactions, within the heart itself, between molecular motifs released by pathogens and their specific receptors, notably those belonging to the toll-like receptor (TLR) family. Here, we determined the ability of bacterial flagellin, the ligand of mammalian TLR5, to trigger myocardial inflammation and contractile dysfunction.
%U http://www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0012687