%0 Journal Article
%T Inhibition of the Nuclear Factor-¦ÊB Pathway Prevents Beta Cell Failure and Diet Induced Diabetes in Psammomys obesus
%A Josefine Friberg
%A Morten F. Tonnesen
%A Schott Heller
%A Flemming Pociot
%A Th¨®ra B. B£¿dvarsdottir
%A Allan E. Karlsen
%J PLOS ONE
%D 2012
%I Public Library of Science (PLoS)
%R 10.1371/journal.pone.0013341
%X High doses of anti-inflammatory drugs, such as aspirin and salicylates, improve glucose metabolism in insulin resistant and type 2 diabetic patients. It has also been shown that the glucose lowering effect is related to the unspecific ability of these drugs to inhibit inhibitor kinase¦Â (IKK¦Â). In this study we have investigated the effect of a selective IKK¦Â-inhibitor on beta cell survival and the prevention of diet induced type 2 diabetes in the gerbil Psammomys obesus (P. obesus).
%U http://www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0013341