%0 Journal Article
%T INFLUENCES OF NOGGIN ON AUTONOMIC NERVOUS SYSTEM DYSFUNCTIONS IN CEREBRAL ISCHEMIA/REPERFUSION RATS<br>Noggin 对脑缺血大鼠自主神经系统活动的影响
%A DU Chun-yun
%A TANG Xiao-jun
%A ZHANG Tao
%A YANG Zhuo
%A <br>杜春芸
%A 汤晓军
%A 张涛
%A 杨卓
%J 生物物理学报
%D 2008
%I 
%X This study examined the responses of the autonomic nervous system (ANS) responses to noggin administration in cerebral ischemia/reperfusion rats. The cerebral ischemia/reperfusion model was established by intermittent occlusion of the common carotid arteries on hyperlipidemia rats. Three groups of Wister rats were used in this study including ischemia/reperfusion operation with intra-cerebroventricular phosphate-buffered saline injection (Veh/stroke group, n=6), ischemia/reperfusion operation with intra-cerebroventricular noggin injection (Noggin/stroke group, n=8) and sham surgery (Control group, n=6). It was found that the percentage power of alpha and theta wave of electroencephalogram (EEG) significantly decreased and that of delta wave was increased in the Veh/stroke group. However, noggin administration reduced the magnitudes of these changes in the group of Noggin/stroke. Moreover, noggin administration not only reduced the ratio of middle and high frequency (MF/HF) bands of HRV, but also decreased the percentage power of renal sympathetic nerve activity at heart rate frequency in group of Noggin/stroke. The results suggest that in the cerebral ischemia/reperfusion rats noggin pre-treatment could be associated with improvement of ANS dysfunction.
%K Noggin
%K Ischemia/reperfusion
%K Autonomic nervous system activity<br>Noggin
%K 脑缺血再灌注
%K 自主神经系统活动
%K Noggin
%K 脑缺血大鼠
%K 神经系统
%K 功能活动
%K 影响
%K CEREBRAL
%K ISCHEMIA
%K AUTONOMIC
%K NERVOUS
%K SYSTEM
%K INFLUENCES
%K RATS
%K 改善作用
%K 异常
%K 自主神经
%K 伤后
%K 脑缺血再灌注
%K 肾交感神经活动
%K 比值
%K 指标
%K 心率变异性
%K 图谱
%K 脑电图
%U http://www.alljournals.cn/get_abstract_url.aspx?pcid=90BA3D13E7F3BC869AC96FB3DA594E3FE34FBF7B8BC0E591&jid=E0C9D9BBED813D6674AC13E942EAC86D&aid=7637BBBC12CC19190F4D61098641CDC7&yid=67289AFF6305E306&vid=B91E8C6D6FE990DB&iid=CA4FD0336C81A37A&sid=23CCDDCD68FFCC2F&eid=659D3B06EBF534A7&journal_id=1000-6737&journal_name=生物物理学报&referenced_num=0&reference_num=26