%0 Journal Article
%T The Application of Homology Modeling in The Cellulase Molecule Evolution<br>同源建模在纤维素酶分子改造中的应用
%A CHEN Xiao-xi
%A CAO Yi-cheng
%A DU Zheng-ping
%A ZENG Bing-jia
%A <br>陈晓曦
%A 曹以诚
%A 杜正平
%A 曾炳佳
%J 生物物理学报
%D 2008
%I 
%X Homology modeling methodology has inspired much new hope for the researches of protein, it solves problems in the protein structure prediction, functional analysis and protein engineering theoretically. Cellulases are increasingly being more important for a large variety of industrial purposes, e.g. within the fuel industry, in the textile industry, in paper pulp processing and so on. Consequently substantial effort has gone into cellulase's cloning, expression and site-directed mutagenesis as well as their structures, functions, and interactions of components of cellulase enzyme systems. However, the reported three-dimensional structures of cellulases from Protein Date Base are not sufficient to the rational design of cellulase mutants, so homology modeling methodology has been applied into molecule artificial evolution of cellulase. Its application mainly includes the mechanism study of functional amino acids, rational design of mutant sites, family homology analysis, structural prediction and functional study of mutants. Along with the development of molecular docking and molecular dynamics simulation, homology modeling will display powerful vitality in the cellulase molecule evolution.
%K Homology modeling
%K Cellulase molecule
%K Rational design
%K Molecular simulation methodology<br>同源建模
%K 纤维素酶分子
%K 理性设计
%K 分子模拟技术
%K 同源建模
%K 纤维素酶
%K 分子改造
%K 应用
%K EVOLUTION
%K MOLECULE
%K CELLULASE
%K HOMOLOGY
%K MODELING
%K 生命力
%K 显示
%K 改造过程
%K 酶分子
%K 计算机模拟技术
%K 分子动力学模拟
%K 分子对接
%K 完善
%K 研究功能
%K 突变体结构
%K 预测
%K 分子结构
%U http://www.alljournals.cn/get_abstract_url.aspx?pcid=90BA3D13E7F3BC869AC96FB3DA594E3FE34FBF7B8BC0E591&jid=E0C9D9BBED813D6674AC13E942EAC86D&aid=89538DAD89430A86013B70A6BF7FD093&yid=67289AFF6305E306&vid=B91E8C6D6FE990DB&iid=0B39A22176CE99FB&sid=CD775AE9DDBD7B53&eid=C753EB8AC8F551B9&journal_id=1000-6737&journal_name=生物物理学报&referenced_num=2&reference_num=26