%0 Journal Article
%T Profilin-1 Is Expressed in Human Atherosclerotic Plaques and Induces Atherogenic Effects on Vascular Smooth Muscle Cells
%A Evren Caglayan
%A Giulio R. Romeo
%A Kai Kappert
%A Margarete Odenthal
%A Michael S¨ądkamp
%A Simon C. Body
%A Stanton K. Shernan
%A Daniel Hackbusch
%A Marius Vantler
%A Andrius Kazlauskas
%A Stephan Rosenkranz
%J PLOS ONE
%D 2012
%I Public Library of Science (PLoS)
%R 10.1371/journal.pone.0013608
%X Profilin-1 is an ubiquitous actin binding protein. Under pathological conditions such as diabetes, profilin-1 levels are increased in the vascular endothelium. We recently demonstrated that profilin-1 overexpression triggers indicators of endothelial dysfunction downstream of LDL signaling, and that attenuated expression of profilin-1 confers protection from atherosclerosis in vivo.
%U http://www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0013608