%0 Journal Article
%T Thiamine Status in Humans and Content of Phosphorylated Thiamine Derivatives in Biopsies and Cultured Cells
%A Marjorie Gangolf
%A Jan Czerniecki
%A Marc Radermecker
%A Olivier Detry
%A Michelle Nisolle
%A Caroline Jouan
%A Didier Martin
%A Fr¨¦d¨¦ric Chantraine
%A Bernard Lakaye
%A Pierre Wins
%A Thierry Grisar
%A Lucien Bettendorff
%J PLOS ONE
%D 2012
%I Public Library of Science (PLoS)
%R 10.1371/journal.pone.0013616
%X Thiamine (vitamin B1) is an essential molecule for all life forms because thiamine diphosphate (ThDP) is an indispensable cofactor for oxidative energy metabolism. The less abundant thiamine monophosphate (ThMP), thiamine triphosphate (ThTP) and adenosine thiamine triphosphate (AThTP), present in many organisms, may have still unidentified physiological functions. Diseases linked to thiamine deficiency (polyneuritis, Wernicke-Korsakoff syndrome) remain frequent among alcohol abusers and other risk populations. This is the first comprehensive study on the distribution of thiamine derivatives in human biopsies, body fluids and cell lines.
%U http://www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0013616