%0 Journal Article
%T DAMAGE TO MEMBRANE LIPIDS AND PROTEINS OF BRAIN MICROSOMES BY HYDROXYL RADICALS<br>羟基自由基对兔脑微粒体膜脂及膜蛋白的损伤
%A 黄芬
%A 梁旭方
%J 生物物理学报
%D 1991
%I 
%X The effect of hydroxyl radical on the lipid peroxidation and (Na + K)-ATPase activity of rabbit brain microsomes has been studied. Results show that hydroxyl radicals induce the lipid peroxidation and increase the formation of malondialdehyde. Incubation of microsomes with hydroxyl radical-generation system results in loss of SH groups and inhibition of (Na + K)-ATPase activity. Addition of sodium ferulate inhibits the lipid peroxidation, effectively protects (Na + K)-ATPase activity and reduces the loss of SH groups. Spin trapping experiments show that sodium ferulate markedly scavenges the hydroxyl radicals.
%K 脑
%K 微粒体
%K 膜脂
%K 膜蛋白
%K 羟基自由基
%U http://www.alljournals.cn/get_abstract_url.aspx?pcid=90BA3D13E7F3BC869AC96FB3DA594E3FE34FBF7B8BC0E591&jid=E0C9D9BBED813D6674AC13E942EAC86D&aid=1C3D6F9F3E271BEA6068091AD5BD0617&yid=116CB34717B0B183&vid=DF92D298D3FF1E6E&iid=0B39A22176CE99FB&sid=E089FDF3CDAE8561&eid=6ED15D8DCB279BC4&journal_id=1000-6737&journal_name=生物物理学报&referenced_num=7&reference_num=1