%0 Journal Article
%T ORTHOLOG--CONCEPT,BIOINFORMATIC INFERENCES AND DATABASES<br>ortholog ——— 概念、生物信息预测方法和数据库
%A CHEN Zuo-zhou
%A ZHU Sheng
%A XUE Cheng-hai
%A CHEN Liang-biao
%A <br>陈作舟
%A 朱晟
%A 薛成海
%A 陈良标
%J 生物物理学报
%D 2004
%I 
%X Orthologs are genes in different species that originate from a single gene in the last common ancestor of these species. Orthologous genes are suggested to share similar functions,be regulated by similar biochemical pathways and play similar roles in different species. Thus, it is the best choice to use orthologous genes when annotating newly discovered genes. There are mainly two categories of algorithms for predictions of orthologs: phylogenetic algorithms and sequence comparison algorithms. Both of them are based on sequence similarities, whereas they have their own characteristics. Phylogenetic ways predict orthologs by reconstructing phylogenetic trees. As a result, they are conceptually accurate, but hard to automate, and demanding huge amount of computational resources. In contrast, the latter methods are conceptually less accurate but not as complex and require less computational resources, therefore, widely used.
%K Ortholog
%K Paralog
%K Duplication
%K Speciation
%K Phylogeny
%K Bioinformatics<br>基因
%K 生物信息学
%K orthologs
%K 数据库
%K 物种
%K 生物信息预测方法
%K 系统发生
%K 序列比对
%U http://www.alljournals.cn/get_abstract_url.aspx?pcid=90BA3D13E7F3BC869AC96FB3DA594E3FE34FBF7B8BC0E591&jid=E0C9D9BBED813D6674AC13E942EAC86D&aid=F057C23C74D33F78&yid=D0E58B75BFD8E51C&vid=A04140E723CB732E&iid=0B39A22176CE99FB&sid=205BE674D84A456D&eid=E22B6B8FE86DD8F9&journal_id=1000-6737&journal_name=生物物理学报&referenced_num=0&reference_num=29