%0 Journal Article
%T UPTAKE OF APOLIPOPROTEIN E-CONTAINIG LIPOPROTEINS BY NEURONS OF THE RAT BRAIN THAT EXPRESS LOW DENSITY LIPOPROTEIN RECEPTORS<br>大白鼠脑中表达低密度脂蛋白(LDL)受体的神经元可吸收含脱辅基蛋白E(ApoE)的脂蛋白
%A 肖悦梅
%A Pitas
%A RE
%A Boyles
%A JK
%J 生物物理学报
%D 1992
%I 
%X In this study, we used fluorescence histological technique in combination with immunocytochemical method to investigate if ApoE-containing lipoprotein can be taken up by neurons of central nervous system in mammals. The results from these experiments are as follows.1. The uptake of labeled ApoE-containing lipoproteins was observed only in neurons distributed along the track of injection.2. The labeled ApoE-containing lipoproteins were internalized by neurons that expressed low density lipoprotein (LDL) receptors.3. Neurons that did not express LDL receptors did not lake up labeled ApoE-containing lipoproteins.Conclusions. Neurons that express LDL receptors have the ability to bind and internalize ApoE-containing lipoproteins present in their environment. This suggests that ApoE-containing lipoproteins and the regulated expression of LDL receptors provide a mechanism for cholesterol transfer and homeostasis within the central nervous system of the mamals.
%K Uptake
%K ApoE-containing lipoprotein
%K LDL Receptor
%K Immunocytoche mistry<br>LDI受体
%K 神经元
%K ApoE
%K 脂蛋白
%U http://www.alljournals.cn/get_abstract_url.aspx?pcid=90BA3D13E7F3BC869AC96FB3DA594E3FE34FBF7B8BC0E591&jid=E0C9D9BBED813D6674AC13E942EAC86D&aid=6F4B2AF07746A9C42ED060F7CBEFB271&yid=F53A2717BDB04D52&vid=5D311CA918CA9A03&iid=38B194292C032A66&sid=238BD7580EFCC5AE&eid=DA74B62FE4348759&journal_id=1000-6737&journal_name=生物物理学报&referenced_num=0&reference_num=0