%0 Journal Article
%T Template-Based Protein Structure Prediction<br>基于模板的蛋白质结构预测
%A HUANG Junfeng
%A DUAN Peng
%A WU Wenyan State Key Laboratory of Biocontrol
%A School of Life Science
%A Sun Yat-Sen University
%A Guangzhou
%A China
%A <br>黄俊峰
%A 段鹏
%A 吴文言
%J 生物物理学报
%D 2011
%I 
%X Methods for predicting three-dimensional structure of protein molecules can be classified into two categories: template-based modeling and template free modeling. Template-based prediction is widely used in application due to its speed and relatively high accuracy. This technique predicts the three-dimensional structure of a given protein sequence based primarily on its alignment to one or more proteins of known structure. In this paper, the progress in the methodology for template-based modeling is reviewed. The critical steps and factors that influence the prediction accuracy are analysed and discussed.
%K Template-based modeling
%K Sequence alignment
%K Model refinement
%K Model selection<br>基于模板的蛋白结构预测
%K 序列比对
%K 结构精修
%K 结构模型筛选
%U http://www.alljournals.cn/get_abstract_url.aspx?pcid=90BA3D13E7F3BC869AC96FB3DA594E3FE34FBF7B8BC0E591&jid=E0C9D9BBED813D6674AC13E942EAC86D&aid=AFDBB91A0BAD929C34513CBFD61BFDF4&yid=9377ED8094509821&vid=DB817633AA4F79B9&iid=CA4FD0336C81A37A&sid=D3E34374A0D77D7F&eid=42425781F0B1C26E&journal_id=1000-6737&journal_name=生物物理学报&referenced_num=0&reference_num=67