%0 Journal Article
%T An Analysis on The Mechanism of Astrocytes Cause Neuronal Hyper-Excitability<br>星形胶质细胞引起神经元超激发的作用机制分析
%A 刘建
%A 杨利建
%A 刘望恒
%A 贾亚
%J 生物物理学报
%D 2011
%I 
%X It is found in experiments that glial cells have a variety of neuro-transmitter receptors on their membrane. Gilial cells can integrate synaptic information and are related to multi- neuron diseases. Based on the existing theoretical work, we investigate the coupling mechanism of astrocytes and neurons by theoretical and numerical method. By stimulating the astrocytes, we got the hyper-excitable state of the neuron, and hyper-excitability is an important feature of epilepsy. Then we analyze the effects of coupling strength on the system, and find that the coupling strength is the key factor leading the neuronal hyper-excitable. These results may give some suggestions when people try to find out the physiological mechanism of epilepsy.
%K Epilepsy
%K Hyper-excitability
%K Tripartite synapses
%K Astrocyte<br>星形胶质细胞
%K 神经元超激发
%K 三向突触
%K 癫痫
%U http://www.alljournals.cn/get_abstract_url.aspx?pcid=90BA3D13E7F3BC869AC96FB3DA594E3FE34FBF7B8BC0E591&jid=E0C9D9BBED813D6674AC13E942EAC86D&aid=A7C3F49386641A929E56A0DE3DB6D1DD&yid=9377ED8094509821&vid=DB817633AA4F79B9&iid=CA4FD0336C81A37A&sid=11B4E5CC8CDD3201&eid=8BD23BD67BF01A5C&journal_id=1000-6737&journal_name=生物物理学报&referenced_num=1&reference_num=26