%0 Journal Article
%T Enhancement of potassium currents in rat dorsal root ganglion neurons by sulfur dioxide derivatives<br>二氧化硫衍生物对大鼠背根神经元瞬间外向钾电流和延迟整流钾电流的影响
%A DU Zheng-qing
%A MENG Zi-qiang
%A <br>杜正清
%A 孟紫强
%J 生物物理学报
%D 2006
%I 
%X This study addressed the effect of sulfur dioxide (SO2) derivatives on transient outward potassium currents (IA and ID) and delayed rectifier current (IK) in somatic membrane of freshly isolated rat dorsal root ganglion neurons using the whole cell configuration of patch-clamp technique. SO2 derivatives reversibly increased the amplitudes of potassium currents in a concentration-dependent and voltage-dependent. SO2 derivatives significantly shifted the activation of delayed rectifier potassium current in the hyperpolarizing direction and shifted the inactivation curve of transient outward potassium currents in the depolarizing direction. Parameters for the fit of a Boltzmann equation to mean values for delayed rectifier current activation were V1/2=20.3±2.1 mV before and 15.0±1.5 mV after application 10 μM SO2 derivatives. The half inactivation of IA was shifted 6 mV and ID 7.4 mV after application 10 μM SO2 derivatives. These results indicated that SO2 derivatives increased the amplitudes of potassium currents and changed the properties of potassium channels.
%K Sulfur dioxide derivatives
%K Transient outward potassium currents
%K Delayed rectifier current
%K Whole-cell patch clamp
%K Dorsal root ganglion<br>二氧化硫衍生物
%K 瞬间外向钾电流
%K 延迟整流钾电流
%K 全细胞膜片钳技术
%K 大鼠背根神经元
%U http://www.alljournals.cn/get_abstract_url.aspx?pcid=90BA3D13E7F3BC869AC96FB3DA594E3FE34FBF7B8BC0E591&jid=E0C9D9BBED813D6674AC13E942EAC86D&aid=0C98DF7582F82D98&yid=37904DC365DD7266&vid=BC12EA701C895178&iid=CA4FD0336C81A37A&sid=2A8D03AD8076A2E3&eid=96C778EE049EE47D&journal_id=1000-6737&journal_name=生物物理学报&referenced_num=0&reference_num=37