%0 Journal Article
%T NETWORK THERMODYNAMICS MODEL OF PATHWAY CONDUCTANCE FOR DRUG TRANSPORT THROUGH SKIN<br>药物经皮转运通道的网络热力学模型
%A BAO Jia-li
%A YANG Yuan-yuan
%A WANG Hong
%A GE Ji-guang
%A WANG Hui-ping
%A <br>包家立
%A 杨媛媛
%A 王红
%A 葛霁光
%A 王会平
%J 生物物理学报
%D 2004
%I 
%X The pathway conductance properties of epidermis for transdermal drug delivery is expounded. Quantitative relationship of the drug permeable flux passing skin with pathway consistency of epidermis in side-by-side permeation chamber is described by network thermodynamics model. It is con-sidered that pathway conductance for drug through skin is regulated by activation and inactivation factors. From completed passive (control) and electrical pulse (experiments) experiments with Tinidazole, the re-sults showed that theoretical curves of pathway conductance of epidermis fitted very well with the data from these experiments. So the conclusion is that initial activation factor (m0), time constant of activation tm), initial inactivation factor (h0), and time constant of inactivation (th) are believed to be very impor-tant indexes for analysis of property of pathway conductance of drug transport through skin.
%K Transdermal drug delivery
%K Pathway conductance
%K Network thermodynamics model<br>经皮给药
%K 通道导纳
%K 网络热力字模型
%U http://www.alljournals.cn/get_abstract_url.aspx?pcid=90BA3D13E7F3BC869AC96FB3DA594E3FE34FBF7B8BC0E591&jid=E0C9D9BBED813D6674AC13E942EAC86D&aid=4631BDCFFAAA2C55&yid=D0E58B75BFD8E51C&vid=A04140E723CB732E&iid=94C357A881DFC066&sid=09AA1448D1EAF9C1&eid=6B3068A7C27BD349&journal_id=1000-6737&journal_name=生物物理学报&referenced_num=2&reference_num=15