%0 Journal Article
%T THE RECEPTOR AGONIST-LIKE EFFECTS OF SAIKOSAPONIN(I) IN ISOLATED RAT PANCREATIC ACINAR CELLS<br>柴胡皂甙(I)对胰腺腺泡的拟膜受体激动剂作用
%A 杨文修
%A 余奕
%A 张文正
%A 王辉
%A 赵玉英
%A 梁鸿
%J 生物物理学报
%D 2001
%I 
%X The effects of Bt2-cGMP and GDP on Saikosaponin and CCK-8 stimulated amylase secretion and i increase were investigated in isolated rat pancreatic acinar cells. Bt2-cGMP inhibited both SA(I) and CCK-8-induced amylase secretions in a dose-dependent way. GDP also inhibited markedly saikosaponin-induced amylase secretion. SA(I) induced i increase in single pancreatic acinar cell was different from that induced by CCK-8: the rising phase of i increase was slow to develop, and lasted longer. In addition, there was a secondary increase after the initial peak. GDP significantly inhibited SA(I)-induces initial peak of i increase. These data indicate that SA(I) may activate i increase and amylase secretion via a direct action on the cell surface receptor.
%K Saikosaponin (I)
%K Pancreatic acini
%K Membrane receptor
%K i
%K Bt2-cGMP
%K GDP<br>柴胡皂甙单体（Ⅰ）
%K 胰腺腺泡
%K 腺受体
%K [Ca^2＋]i
%K Bt2－cGMP
%K GDP
%K 受体激动剂
%K 酶分泌
%K 剂量
%U http://www.alljournals.cn/get_abstract_url.aspx?pcid=90BA3D13E7F3BC869AC96FB3DA594E3FE34FBF7B8BC0E591&jid=E0C9D9BBED813D6674AC13E942EAC86D&aid=99F4B69AA7F60451&yid=14E7EF987E4155E6&vid=BCA2697F357F2001&iid=0B39A22176CE99FB&sid=A1266CF37D675CF1&eid=CA5852BD1A173B3A&journal_id=1000-6737&journal_name=生物物理学报&referenced_num=4&reference_num=10