%0 Journal Article
%T STUDY OF HYPOCRELLIN A PHOTOSENSITIZATION INDUCED MUTAGENESIS IN CHO CELL<br>竹红菌甲素（HA）光敏致实作用的研究
%A 许娜飞
%A 曹恩华
%A 李景福
%J 生物物理学报
%D 1995
%I 
%X The mutation effect of Hypoerellin A on CHO Cell was studied by analysis of the mutantdefedn in Na+/K+ATPase gene induce by HA photosensidrition and then selected byouabain. The result shoal that HA photosensithation has the ability to cause cell DNA pointmutation and the mutant remains stable following propagation in the absence of ouabain. Thisis conirmed by enzyme assay. Further the analysis of lipid peroxidation deggree of CHO Celltreated with different condition of HA and light together with the observation of thefluousere of DNA-lipid peroxidation products suggests that the lipid peroxidation causedby HA photosensithation plays an important role in the Cell DNA damage and gene mutation.
%K Hypocrellin A
%K CHO Cell
%K Photosensitization
%K Gene mutation
%K Lipid peroxidation<br>光敏剂
%K 竹红菌甲素
%K 光敏反应
%K 致突变
%K 药理学
%U http://www.alljournals.cn/get_abstract_url.aspx?pcid=90BA3D13E7F3BC869AC96FB3DA594E3FE34FBF7B8BC0E591&jid=E0C9D9BBED813D6674AC13E942EAC86D&aid=8760C2861E15B2FE29960914ED3A8214&yid=BBCD5003575B2B5F&vid=708DD6B15D2464E8&iid=E158A972A605785F&sid=1A0C7C60D40EFD74&eid=C7B13290323C226E&journal_id=1000-6737&journal_name=生物物理学报&referenced_num=2&reference_num=11