%0 Journal Article
%T STUDIES OF RELATIONS OF GLUTAMATE UPTAKE BY ASTROCYTE WITH ENVIROMENT FACTORS AND ION TRANSPORT<br>星形神经胶质细胞摄取谷氨酸与环境因子和离子运输的关系
%A 庞素珍
%A H.K.Kimelberg
%J 生物物理学报
%D 1990
%I 
%X Astrocyte cultures and radioisotopic tracer method were used in this study. The effects of ions (Na-, K+, Cl-), of different concentration of kainic acidand of some inhibitors in media on uptake of L-glutamate and influence of L-glutamate uptake on Na+, K+, Cl-, Ca2+ ion transport on cell membrane were explored. The results suggest that the uptake of L-glutamate depended on the concentration of Na + . Also, it depended obviously on concentration of Cl- in the absence of Na+ in media, but not in the pre-sence of phsiological concentration of Na + . The glutamate uptake was decreased when K- concentration was increased which caused depolarization. On the other hand, glutamate uptake stimulated the transports of Na+, K+, Cl-. The results also show that uptake of glutamate was inhibited by 10-3 or 10-2 M Kainic acid and the inhibitors used.
%K 神经胶质细胞
%K 谷氨酸
%K 环境因子
%U http://www.alljournals.cn/get_abstract_url.aspx?pcid=90BA3D13E7F3BC869AC96FB3DA594E3FE34FBF7B8BC0E591&jid=E0C9D9BBED813D6674AC13E942EAC86D&aid=33065D87B9A63FA37AEB6EBFF85815B4&yid=8D39DA2CB9F38FD0&vid=B31275AF3241DB2D&iid=38B194292C032A66&sid=31125890FF093250&eid=35E8A259891FB32F&journal_id=1000-6737&journal_name=生物物理学报&referenced_num=0&reference_num=0