%0 Journal Article
%T Plasma Biochemical Parameters as Surrogate Prognostic Markers in HIV-1 Infected Patients
%A O.A. Ajose
%A S.O. Banjoko
%A O.A. Olasode
%A V.A. Oyegunle
%A J.B. Fakunle
%J Research Journal of Medical Sciences
%D 2012
%I 
%X The depression of the immune system accompanied by different metabolic derangements which are worsened by secondary infections are responsible for morbidity and subsequent mortality in HIV-1 infected patients. While, the gold standard prognostic marker for the infection remains the CD4+T lymphocyte count, plasma biochemical markers are potential surrogate prognostic markers. Samples obtained from 100 consecutively diagnosed HIV-1 infected patients who were not on anti retroviral therapy and equal number of apparently healthy seronegative individuals as controls were analysed for urea, creatinine total protein, albumin, globulin and albumin: globulin ratio using kits obtained from Randox laboratorie, U.K. spectrophotometrically and Na+, K+ and HCO3 ions concentration using the ion selective electrode analyzer. obtainable from Hitachi, Japan. Compared to the controls, statistically significant differences were observed in the plasma concentrations of HCO3 (p<0.001) urea (p<0.005) creatinine (p<0.001), total protein (p<0.001), albumin (p<0.0001) globulin (p<0.001) and albumin: Globulin ratio (p<0.0001). However, no significant difference were observed in the Na+ and K+ ion concentrations with p values of 0.10 and 0.25, respectively. Those significantly different plasma biochemical parameters can therefore be useful surrogate prognostic markers for HIV-1 infections in resource limited settings.
%U http://www.medwellonline.net/abstract/?doi=rjmsci.2008.163.165