%0 Journal Article
%T Plasminogen Activator Inhibitor-1-675 4G/5G and Methylenetetrahydrofolate Reductase Gene Variants in Young Acute Myocardial Infarction and Juvenile Ischemic Stroke
%A Giulia Bivona
%A Chiara Bellia
%A Salvatore Cammarieri
%A Bruna Lo Sasso
%A Rosachiara Carollo
%A Rosalinda Raineri
%A Gaia Chiarello
%A Antonietta Caruso
%A Marcello Ciaccio
%J Research Journal of Biological Sciences
%D 2012
%I Medwell Online
%X Cardiovascular diseases often recognize a hereditary-familial genetic risk patterns and a substantial proportion of variability in clinical features of atherosclerosis could probably be explained by genetic factors. Aim of this study is to compare prevalence of factor V Leiden, factor II 20210A, PAI-1-675 4G/5G and MTHFR C677T gene variants in 2 cardiovascular disease clinical features: young acute myocardial infarction (<50 years) and ischemic stroke. Plasminogen Activator Inhibitor-1-675 4G/5G didn t show significant difference between patients and controls while, between patient groups, the polymorphism was most present in myocardial infarction group than in juvenile stroke. Polymorphisms in Homocysteine metabolism: MTHFR C677T variants was significantly higher in patients with myocardial infarction compared with those affected by ischemic Stroke.
%U http://www.medwellonline.net/abstract/?doi=rjbsci.2008.1341.1343