%0 Journal Article
%T Idiopathic Male Infertility Is Strongly Associated with Aberrant Promoter Methylation of Methylenetetrahydrofolate Reductase (MTHFR)
%A Wei Wu
%A Ouxi Shen
%A Yufeng Qin
%A Xiaobing Niu
%A Chuncheng Lu
%A Yankai Xia
%A Ling Song
%A Shoulin Wang
%A Xinru Wang
%J PLOS ONE
%D 2012
%I Public Library of Science (PLoS)
%R 10.1371/journal.pone.0013884
%X Abnormal germline DNA methylation in males has been proposed as a possible mechanism compromising spermatogenesis of some men currently diagnosed with idiopathic infertility. Previous studies have been focused on imprinted genes with DNA methylation in poor quality human sperms. However, recent but limited data have revealed that sperm methylation abnormalities may involve large numbers of genes or shown that genes that are not imprinted are also affected.
%U http://www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0013884