%0 Journal Article
%T Baseline Prediction of Combination Therapy Outcome in Hepatitis C Virus 1b Infected Patients by Discriminant Analysis Using Viral and Host Factors
%A Ver¨®nica Saludes
%A Maria Alma Bracho
%A Oliver Valero
%A Merc¨¨ Ard¨¨vol
%A Ram¨®n Planas
%A Fernando Gonz¨¢lez-Candelas
%A Vicente Ausina
%A Elisa Martr¨®
%J PLOS ONE
%D 2012
%I Public Library of Science (PLoS)
%R 10.1371/journal.pone.0014132
%X Current treatment of chronic hepatitis C virus (HCV) infection has limited efficacy £¿especially among genotype 1 infected patients£¿, is costly, and involves severe side effects. Thus, predicting non-response is of major interest for both patient wellbeing and health care expense. At present, treatment cannot be individualized on the basis of any baseline predictor of response. We aimed to identify pre-treatment clinical and virological parameters associated with treatment failure, as well as to assess whether therapy outcome could be predicted at baseline.
%U http://www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0014132