%0 Journal Article
%T Lysophosphatidic Acid Acyltransferase ¦Â (LPAAT¦Â) Promotes the Tumor Growth of Human Osteosarcoma
%A Farbod Rastegar
%A Jian-Li Gao
%A Deana Shenaq
%A Qing Luo
%A Qiong Shi
%A Stephanie H. Kim
%A Wei Jiang
%A Eric R. Wagner
%A Enyi Huang
%A Yanhong Gao
%A Jikun Shen
%A Ke Yang
%A Bai-Cheng He
%A Liang Chen
%A Guo-Wei Zuo
%A Jinyong Luo
%A Xiaoji Luo
%A Yang Bi
%A Xing Liu
%A Mi Li
%A Ning Hu
%A Linyuan Wang
%A Gaurav Luther
%A Hue H. Luu
%A Rex C. Haydon
%A Tong-Chuan He
%J PLOS ONE
%D 2012
%I Public Library of Science (PLoS)
%R 10.1371/journal.pone.0014182
%X Osteosarcoma is the most common primary malignancy of bone with poorly characterized molecular pathways important in its pathogenesis. Increasing evidence indicates that elevated lipid biosynthesis is a characteristic feature of cancer. We sought to investigate the role of lysophosphatidic acid acyltransferase ¦Â (LPAAT¦Â, aka, AGPAT2) in regulating the proliferation and growth of human osteosarcoma cells. LPAAT¦Â can generate phosphatidic acid, which plays a key role in lipid biosynthesis as well as in cell proliferation and survival. Although elevated expression of LPAAT¦Â has been reported in several types of human tumors, the role of LPAAT¦Â in osteosarcoma progression has yet to be elucidated.
%U http://www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0014182