%0 Journal Article
%T TLR4 Inhibits Mesenchymal Stem Cell (MSC) STAT3 Activation and Thereby Exerts Deleterious Effects on MSC¨CMediated Cardioprotection
%A Yue Wang
%A Aaron M. Abarbanell
%A Jeremy L. Herrmann
%A Brent R. Weil
%A Mariuxi C. Manukyan
%A Jeffrey A. Poynter
%A Daniel R. Meldrum
%J PLOS ONE
%D 2012
%I Public Library of Science (PLoS)
%R 10.1371/journal.pone.0014206
%X Bone marrow-derived mesenchymal stem cells (MSC) improve myocardial recovery after ischemia/reperfusion (I/R) injury. These effects are mediated in part by the paracrine secretion of angiogenic and tissue growth-promoting factors. Toll-like receptor 4 (TLR4) is expressed by MSC and induces apoptosis and inhibits proliferation in neuronal progenitors as well as many other cell types. It is unknown whether knock-out (KO) of TLR4 will change the paracrine properties of MSC and in turn improve MSC-associated myocardial protection.
%U http://www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0014206