%0 Journal Article
%T Nitration of the Egg-Allergen Ovalbumin Enhances Protein Allergenicity but Reduces the Risk for Oral Sensitization in a Murine Model of Food Allergy
%A Eva Untersmayr
%A Susanne C. Diesner
%A Gertie Janneke Oostingh
%A Kathrin Selzle
%A Tobias Pfaller
%A Cornelia Schultz
%A Yingyi Zhang
%A Durga Krishnamurthy
%A Philipp Starkl
%A Regina Knittelfelder
%A Elisabeth F£¿rster-Waldl
%A Arnold Pollak
%A Otto Scheiner
%A Ulrich P£¿schl
%A Erika Jensen-Jarolim
%A Albert Duschl
%J PLOS ONE
%D 2012
%I Public Library of Science (PLoS)
%R 10.1371/journal.pone.0014210
%X Nitration of proteins on tyrosine residues, which can occur due to polluted air under ¡°summer smog¡± conditions, has been shown to increase the allergic potential of allergens. Since nitration of tyrosine residues is also observed during inflammatory responses, this modification could directly influence protein immunogenicity and might therefore contribute to food allergy induction. In the current study we have analyzed the impact of protein nitration on sensitization via the oral route.
%U http://www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0014210