%0 Journal Article
%T Nuclear Shield: A Multi-Enzyme Task-Force for Nucleus Protection
%A Raffaele Fabrini
%A Alessio Bocedi
%A Valentina Pallottini
%A Lorena Canuti
%A Michele De Canio
%A Andrea Urbani
%A Valeria Marzano
%A Tommaso Cornetta
%A Pasquale Stano
%A Anna Giovanetti
%A Lorenzo Stella
%A Antonella Canini
%A Giorgio Federici
%A Giorgio Ricci
%J PLOS ONE
%D 2012
%I Public Library of Science (PLoS)
%R 10.1371/journal.pone.0014125
%X In eukaryotic cells the nuclear envelope isolates and protects DNA from molecules that could damage its structure or interfere with its processing. Moreover, selected protection enzymes and vitamins act as efficient guardians against toxic compounds both in the nucleoplasm and in the cytosol. The observation that a cytosolic detoxifying and antioxidant enzyme i.e. glutathione transferase is accumulated in the perinuclear region of the rat hepatocytes suggests that other unrecognized modalities of nuclear protection may exist. Here we show evidence for the existence of a safeguard enzyme machinery formed by an hyper-crowding of cationic enzymes and proteins encompassing the nuclear membrane and promoted by electrostatic interactions.
%U http://www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0014125