%0 Journal Article
%T Engineering the Chloroplast Targeted Malarial Vaccine Antigens in Chlamydomonas Starch Granules
%A David Dauvill¨¦e
%A St¨¦phane Delhaye
%A S¨¦bastien Gruyer
%A Christian Slomianny
%A Samuel E. Moretz
%A Christophe d'Hulst
%A Carole A. Long
%A Steven G. Ball
%A Stanislas Tomavo
%J PLOS ONE
%D 2012
%I Public Library of Science (PLoS)
%R 10.1371/journal.pone.0015424
%X Malaria, an Anopheles-borne parasitic disease, remains a major global health problem causing illness and death that disproportionately affects developing countries. Despite the incidence of malaria, which remains one of the most severe infections of human populations, there is no licensed vaccine against this life-threatening disease. In this context, we decided to explore the expression of Plasmodium vaccine antigens fused to the granule bound starch synthase (GBSS), the major protein associated to the starch matrix in all starch-accumulating plants and algae such as Chlamydomonas reinhardtii.
%U http://www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0015424