%0 Journal Article
%T Uptake of Aggregating Transthyretin by Fat Body in a Drosophila Model for TTR-Associated Amyloidosis
%A Malgorzata Pokrzywa
%A Ingrid Dacklin
%A Monika Vestling
%A Dan Hultmark
%A Erik Lundgren
%A Rafael Cantera
%J PLOS ONE
%D 2012
%I Public Library of Science (PLoS)
%R 10.1371/journal.pone.0014343
%X A functional link has been established between the severe neurodegenerative disorder Familial amyloidotic polyneuropathy and the enhanced propensity of the plasma protein transthyretin (TTR) to form aggregates in patients with single point mutations in the TTR gene. Previous work has led to the establishment of an experimental model based on transgenic expression of normal or mutant forms of human TTR in Drosophila flies. Remarkably, the severity of the phenotype was greater in flies that expressed a single copy than with two copies of the mutated gene.
%U http://www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0014343